Abstract
BackgroundThere is evidence that opium addiction has immunosuppressant effects. Coronary artery disease (CAD) is a condition resulted from atherosclerosis which is dependent on the immune response.PurposeTo evaluate plasma levels of interleukin-6 and interleukin-1Ra in 30 patients with three-vessel coronary artery disease, ejection fraction of more than 35% and to evaluate their changes after prognostic treadmill test in 15 opium addicted and 15 non-addicted patients.MethodsThe participants underwent prognostic treadmill test and plasma levels of interleukin-6 (IL-6) and interleukin-1Ra (IL-1Ra) were evaluated with ELISA method before, just after and 4 hours after the test.ResultsIL-1Ra (2183 pg/ml) tended to decrease over time in the opium addicted group (1372 pg/ml after prognostic treadmill test and 1034 pg/ml 4 hours after that), although such decrease did not reach the statistical significance. IL-1Ra levels were significantly higher in opium addicted than in non addicted patients. Opium addiction had no significant effect on IL-6 changes.ConclusionConsumption of opium in CAD patients is associated with higher IL-1Ra levels.
Highlights
Atherosclerosis is a chronic inflammatory process, which is characterized by leukocyte proliferation and migration of smooth muscle cells, matrix formation, revascularization and cytokine formation [1]
Consumption of opium in Coronary artery disease (CAD) patients is associated with higher IL-1Ra levels
IL-1Ra and IL-6 are significantly increased in coronary artery disease (CAD) patients compared with healthy individuals [4,5]
Summary
Atherosclerosis is a chronic inflammatory process, which is characterized by leukocyte proliferation and migration of smooth muscle cells, matrix formation, revascularization and cytokine formation [1]. IL-1Ra and IL-6 are significantly increased in coronary artery disease (CAD) patients compared with healthy individuals [4,5]. Within 2 h after heroin administration, proliferative responses to alloantigens and the production of IL-1b, IFN-c, IL-12 and NO were enhanced significantly in mice spleen cells. Coronary artery disease (CAD) is a condition resulted from atherosclerosis which is dependent on the immune response. Purpose: To evaluate plasma levels of interleukin-6 and interleukin-1Ra in 30 patients with three-vessel coronary artery disease, ejection fraction of more than 35% and to evaluate their changes after prognostic treadmill test in 15 opium addicted and 15 non-addicted patients
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
