Abstract
Opioids induce dual (inhibitory and excitatory) regulation of depolarization-evoked [ 3H]dopamine release in SK-N-SH cells through either μ or δ receptors. The potentiation of dopamine release by opioid agonists is mediated by N-type voltage-dependent calcium channels and does not involve G i/G o proteins. Removal of the excitatory opioid effect by blockade with ω-conotoxin, an N-channel antagonist, reveals the inhibitiory effect of opioids on release, thus suggesting that both modulatory effects of opioids are exerted in parallel.
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