Abstract
Opioids have been considered to exert their analgesic effects through actions within the central nervous system. Successful opioid therapy requires that analgesia be achieved without excessive adverse effects. Opioid side effects impair the quality of life, increase morbidity, and may cause a patient to discontinue therapy. The aim of this chapter is to examine the principal mechanisms underlining opioid-related adverse effects and specific adjuvant drugs most commonly used able to counteract these symptoms.
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