Abstract
We determine the opioid peptide content in the rat brain during the ictal phase and postictal depression after pentylenetetrazol kindling rats. Radioimmunoassays with highly specific antisera risen for Met-enkephalin, Leu-enkephalin and octapeptide, were carried out during the ictal phase, and 15, 30 and 60 min after seizures. We always found an initial IR-Met-enkephalin decrease during the postictal depression content, followed by a reduction in IR-Leu-enkephalin and IR-octapeptide tissular concentration. We suggest a functional and differential release of the opioid peptides, during the postictal depression time-course.
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