Abstract
The use of opioids for perioperative pain management in children with pediatric airway and tonsillectomy procedures results in clinical challenges because of reported postoperative deaths and life-threatening respiratory depression. This is especially a major concern in children with significant obstructive sleep apnea. This chapter reviews opioid metabolism, genetic factors that affect opioid metabolism, adverse postoperative outcomes, and management of opioid overdose in children undergoing airway procedures.
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