Abstract
Two imaging reports in this volume highlight the importance of the interaction between the brain's opioid and dopamine (DA) systems in the reinforcing and addictive effects of substances of abuse. These studies use positron emission tomography (PET) to measure, in one instance ( 1 Urban N.B.L. Lawrence M. Slifstein M. Xu X. Martinez D. et al. Sex differences in striatal dopamine release in young adults after oral alcohol challenge: A positron emission tomography imaging study with [11C]raclopride. Biol Psychiatry. 2010; 68: 689-696 Abstract Full Text Full Text PDF PubMed Scopus (140) Google Scholar ), changes in DA induced by acute alcohol administration in healthy subjects (with [11C] raclopride, a radioligand that binds to D2 and D3 receptors (D2R and D3R) and that is sensitive to competition with endogenous DA) and, in the other ( 2 Ghitza U. Preston K.L. Epstein D.H. Kuwabara H. Endres C.J. Bencherif B. et al. Brain mu-opioid receptor binding predicts treatment outcome in cocaine-abusing outpatients. Biol Psychiatry. 2010; 68: 697-703 Abstract Full Text Full Text PDF PubMed Scopus (54) Google Scholar ), μ opioid receptor (mOR) availability in cocaine abusers (with [11C] carfentanil, an mOR specific radioligand). Sex Differences in Striatal Dopamine Release in Young Adults After Oral Alcohol Challenge: A Positron Emission Tomography Imaging Study With [11C]RacloprideBiological PsychiatryVol. 68Issue 8PreviewWe used a positron emission tomography paradigm with the D2/3 radiotracer [11C]raclopride and an alcohol challenge to examine the magnitude of alcohol-induced dopamine release and compare it between young men and women. Full-Text PDF Brain Mu-Opioid Receptor Binding Predicts Treatment Outcome in Cocaine-Abusing OutpatientsBiological PsychiatryVol. 68Issue 8PreviewCocaine users not seeking treatment have increased regional brain mu-opioid receptor (mOR) binding that correlates with cocaine craving and tendency to relapse. In cocaine-abusing outpatients in treatment, the relationship of mOR binding and treatment outcome is unknown. Full-Text PDF
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
