Opioid conversions and patient-controlled analgesia parameters in opioid-dependent patients

Abstract

To the Editor, While a recent Continuing Professional Development article outlined the perioperative management of patients taking opioids for chronic pain, others have highlighted the serious consequences of opioid use in these patients. Patients who need opioids for pain prior to their surgery almost always require these to be continued throughout the perioperative period. ‘‘Conversion’’ tables have been developed to calculate the parenteral equivalent of oral opioids. The conventional conversion ratio between oral and intravenous routes for morphine or hydromorphone is considered to be threefold (3:1); however, for patients on long-term or escalating doses of opioids, multiple conversion ratios have also been advocated. Due to the uncertainty regarding the exact conversion ratio in the individual patient, we suggest that it is best to assume that the oral to intravenous ratio is high when converting extended-release oral tablets to intravenous opioids. On the contrary, it is safer to use a low intravenous to oral ratio when converting from intravenous opioids to oral tablets. To estimate the new dose, we recommend that two different ratios be used depending on the ‘‘direction’’ of conversion, i.e., 4:1 for oral to intravenous and 1:2 for intravenous to oral, as shown in the Dual Ratio Opioid Conversion Chart we have developed to manage acute pain in opioid dependent patients (Figure). These dual ratios provide a conservative estimate for a new opioid dose, and depending on the direction of conversion, they provide a 25% or 33% reduction when compared with the conventional threefold ratio. The second challenge in opioid-dependent patients requiring patient-controlled analgesia (PCA) is to set appropriate parameters. For those who are unable to take oral opioids in the perioperative period, we add a basal infusion for half the hourly intravenous equivalent (Figure). During the stable maintenance phase for effective analgesia, patients should not require more than two PCA boluses per hour on average. This appropriate bolus-demand frequency is dependent upon an appropriately chosen bolus size. To determine the PCA bolus size in opioid-dependent patients, the opioid dose-response should be compared with that of an opioid-naive patient in whom the standard morphine PCA bolus size is 1 mg. The magnitude of the shift of the opioid dose-response curve is calculated by dividing the daily oral morphine equivalent by 100 mg and multiplying the standard bolus size (1 mg of morphine) by this factor. For example, a patient taking 400 mg per day of oral morphine preoperatively has approximately a fourfold (400/100 = 4) increase in opioid requirement and would require a 4 mg PCA bolus dose. For such a patient, the starting PCA settings would be a 4 mg bolus, a basal infusion rate of 2 mg hr, a lockout interval of six minutes, and an hourly limit of 32 mg. At the end of the perioperative phase, if this patient requires 100 mg of intravenous morphine per day for adequate analgesia, we would recommend 200 mg of oral morphine in divided doses for oral use based on the Dual Ratio Opioid Conversion Chart. Richebe et al. suggested setting the continuous (basal) infusion equivalent to the total preoperative opioid use and keeping the bolus dose unchanged. Previously, Hadi et al. suggested setting half of the preoperative dose as the basal and increasing the bolus dose by 50%. Both of these This work should be attributed to the Department of Anesthesiology, The Ottawa Hospital, Ottawa.