Abstract
Approximately one-fifth of patients treated with statins experience myalgias that lead to cessation of therapy. Currently, there is no optimal treatment for patients who develop statin-associated myalgias (SAMs) but who still require treatment for hyperlipidemia. Because of SAM, patients may seek alternative therapies to manage their hypercholesterolemia, including red yeast rice, a widely available dietary supplement that lowers low-density lipoprotein cholesterol by 25% to 30% and has been shown in small trials to be well-tolerated in patients with a history of SAM.
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