Abstract
Bioavailability, drug delivery, phospholipid, phytochemical, phytosome. During the past two decades, it has become well-known that phytomedicines could be successfully employed to treat several types of human diseases. However, low systemic bioavailability is commonly referred to as a major obstacle to achieve the maximum efficacy of phytomedicines in clini-cal practice. This low bioavailability is mainly due to either highly polar and water soluble, or strong lipophilic nature of some phytochemicals, causing hydrophilic lipophilic balance values that hinder complete passage of phytochemical through either unstirred water layer covering brush border or plasma membrane of enterocytes [1]. To overcome these limitations, majoradvances have been made using novel drug delivery systems [2]. Phytosome is a biocompatible and bio-degradable delivery system that is formed through com-plexation –in an stoichiometric ratio-of a phytochemical, or a mixture of phytochemicals, with a phospholipid, mainly phosphatidylcholine or phosphatidylserine, in an aprotic sol-vent [3] Fig. (
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