Opiate receptors in idiopathic generalised epilepsy measured with [ 11C]diprenorphine and positron emission tomography

Abstract

The neurochemical basis of absence seizures is uncertain. A previous PET study has provided evidence for release of endogenous opioids from cerebral cortex at the time of absence seizures, but it is has not yet been established whether there is an abnormality of opiate receptor numbers interictally. In the present study, the non-specific opiate receptor ligand, [ 11C]diprenorphine, was used to measure cerebral opiate receptors interictally in patients with childhood and juvenile absence epilepsy. Eight patients and eight normal controls had a single scan after a high specific activity injection of [ 11C]diprenorphine. The cerebral volume of distribution (V d) of [ 11C]diprenorphine relative to plasma was calculated on a pixel-by-pixel basis. There were no significant differences in [ 11C]diprenorphineV dbetween patients and control subjects in either cortex or thalamus, structures thought to be involved in the pathogenesis of absence seizures. The results suggest that there is no overall abnormality of opioid receptors in patients with childhood and juvenile absence epilepsy. Studies with specific ligands may provide information about the different receptor subtypes.