Abstract
Electroconvulsive shock (ECS) in rats produced a generalized seizure which was followed by an opiate-like catalepsy and an increase in hot-plate escape latencies. Preinjection of naloxone, at doses of 3.0 and 10.0 mg/Kg, significantly diminished the ECS-induced increase in hot-plate latencies. Paradoxically, simultaneous measurement of tail-flick latencies in these same rats demonstrated opiate- agonist effects of naloxone. The cataleptic effects of ECS were demonstrated to be opiate-like by evaluating righting reflexes, grid responses, and haloperidol effects. Colonic temperatures were also measured in all animals. These data, collectively discussed relative to affective and reflexive components of nociceptive behaviors, support the hypothesis that selective endorphin systems are activated by ECS. Moreover, these observations suggest consideration of a role for endorphin systems in the therapeutic mechanisms of electroconvulsive therapy (ECT) in man.
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