Abstract
The therapeutic effectiveness of a drug may be profoundly influenced by the vehicle in which it is administered. This is especially true of ophthalmic medication. Three formulations were investigated on nine individuals, aged 15-30, to determine their effectiveness as aqueous ophthalmic vehicles for homatropine hydrobromide. They were identical in electrolyte content, preservative content, and pH, but differed in methylcellulose content. They contained 1 per cent methylcellulose, 0.1 per cent methylcellulose, or no methylcellulose. Homatropine hydrobromide administered in 1 per cent methylcellulose induced greater cydoplegia and mydriasis at almost all doses. It is believed that the greater effectiveness is probably a result of increased viscosity rather than a lowering of surface tension caused by the methylcellulose. The methylcellulose reduced reflex lachrymation and caused no eye irritation or damage. The technique used provides a simple efficient method for further development and testing of new ophthalmic vehicles.
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