Abstract
An in vitro method using ovine eyes was used to evaluate bioavailability of chloramphenicol from ophthalmic ointment and solution preparations. The results obtained were consistent with the findings of other studies using rabbit and human subjects verifying the usefulness of this in vitro technique. It was apparent that the ointment tested gave better ophthalmic levels of chloramphenicol than the solution and the former is therefore preferable in the treatment of ocular infections.
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