Abstract
FAVORABLE reports have been made on the treatment of certain surface infections of the border of the lid, the conjunctiva and the cornea with penicillin ointments. Florey and Florey 1 used a penicillin salve with a pure petrolatum base. Keyes 2 applied penicillin in a wool fat and cold cream base, and Cashell 3 in a lanette wax base. 4 In an earlier experimental investigation in this laboratory 5 the penetrability of three ointments, representing two types of emulsion systems (anhydrous wool fat containing 10 per cent liquid petrolatum and an oil-in-water emulsion) was studied; similar investigations were conducted by Bellows 6 with four bases and by Leopold and LaMotte 7 with a Carbowax (a polyethylene glycol) base. The cited experimental studies were, however, concerned mostly with the penetration from a few ointments, generally containing the sodium salt of penicillin. It was desirable, therefore, to extend the investigations and to
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