Abstract
The microemulsion systems, o/w, composed of castor oil, sesame oil, arachis oil, olive oil, polysorbate 20, polysorbate 80, Tyloxapol, Carbomer 974P, carboxymethyl cellulose sodium, hydroexthylecellulose, glycerine, propylene glycol, sodium chloride and purified water, taken at various amounts and in various combinations, were tested in order to assess their physical-chemical compatibility. All ingredients of the microemulsions were physiologically acceptable. Microemulsions were evaluated for the different parameters to access the effect of processing parameters on the globule size formation and stability. The stable microemulsion system was obtained for the formulation in which castor oil and polysorbate 80 was used. The following parameters were analyzed: description, pH, osmolality, viscosity, specific gravity, globule size, polydispersity index (PDI) zeta potential, surface tension, assay, in vitro Drug Release. The study made it possible to select the most stable microemulsion system meeting the requirements of eye drops. Thus, the proposed formulation and process were successfully developed and evaluated.
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