Abstract

Whether operative treatment for complex proximal humeral fractures (CPHFs) has a greater benefit over non-operative treatment remains controversial. There is no consensus on the optimal treatment in elderly patients with CPHFs. This updated meta-analysis of randomized controlled trials (RCTs) aims to investigate whether operative treatment is superior to non-operative treatment in CPHFs. The authors searched RCTs in the electronic databases (Cochrane Central Register of Controlled Trials, PubMed, EMBASE, Medline, Embase, Springer Link, Web of Knowledge, OVID and Google Scholar) from their establishment to July 2015. Researches on operative and non-operative treatment for CPHFs were selected in this meta-analysis. The quality of all studies was assessed and effective data was pooled for this meta-analysis. Outcome measurements were functional status include constant scores (CS scores) and disabilities of the arm, shoulder and hand scores (DASH scores), total complication rates and healthy-related quality of life. The meta-analysis was performed with software revman 5.3. Nine articles with a total 518 patients (average age 70.93) met inclusion criteria. Patients were followed up for at least 1 year in all the studies. No statistical differences were found between operative and non-operative treatment in CS scores at 12 mo (months) [MD 1.06 95 % CI (−3.51, 5.62)] and 24 mo [MD −0.61 95 % CI (−5.87, 4.65)]. There are also no statistical differences between operative and non-operative treatment in DASH scores at 12 mo [MD −4.51 95 % CI (−13.49, 4.47)] and 24 mo [MD −7.43 95 % CI (−16.14, 1.27)]. Statistical differences were found between operative and non-operative treatment in total complication rates [RR 1.55, 95 % CI (1.24, 1.94)]. Statistical differences in EQ-5D at 24 mo [MD 0.15, 95 % CI (0.05, 0.24)] were found between operative and non-operative treatment but no statistical differences were found in ED-5D at 12 mo [MD 0.08, 95 % CI (−0.01, 0.17)], 15D at 12 mo [MD 0.02, 95 % CI (−0.68, 0.73)] and 15D at 24 mo [MD 0.02, 95 % CI (−0.07, 0.83)]. Operative treatments did not significantly improve the functional outcome and healthy-related quality of life in elderly patients. Instead, Operative treatment for CPHFs led to higher incidence of postoperative complications.

Highlights

  • Proximal humeral fractures are common injuries that comprises 5–6 % of all adult fractures, with the incidence of 63.0/105 per year (Bengner et al 1988; BaronXie et al SpringerPlus (2015) 4:72815 % displaced fractures which are challenge to surgeons can be treated with operative or non-operative treatment (Kim et al 2012; Handoll and Ollivere 2010)

  • This updated meta-analysis of randomized controlled trials (RCTs) aims to investigate whether operative treatment is superior to non-operative treatment in complex proximal humeral fractures (CPHFs)

  • Our analysis shows that operative treatment has no significant benefit on shoulder and arm functional recovery compared to non-operative treatment

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Summary

Introduction

Proximal humeral fractures are common injuries that comprises 5–6 % of all adult fractures, with the incidence of 63.0/105 per year (Bengner et al 1988; BaronXie et al SpringerPlus (2015) 4:72815 % displaced fractures which are challenge to surgeons can be treated with operative or non-operative treatment (Kim et al 2012; Handoll and Ollivere 2010). Meta-analysis comparing conservation with operative treatment for proximal humeral fractures have been available in recent years (Sun et al 2015; Mao et al 2014; Jia et al 2014; Fu et al 2014; Li et al 2013). They did not improve evidence-based decision making because of lack of RCTs. Recently, several RCTs have investigated whether operative treatment may provide greater benefits than non-operative treatment (Rangan et al 2015; Fjalestad and Hole 2014; Fjalestad et al 2010, 2012; Boons et al 2012; Olerud et al 2011a, b; Zyto et al 1997; Stableforth 1984).

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