Operative Therapy of Parkinson's Disease and the Role of Neurologist

Abstract

Dopaminergic agents are still the mainstay of therapy in Parkinson's disease. Such dopamine replacement therapy results in a reduction in motor symptoms in the early stages of the disease. However, dopaminergic agents will cause motor (motor fluctuations and dyskinesia) and nonmotor (sensory, autonomic, and psychiatric) complications, 50% will occur after 5 years, The operative approach has been shown to be effective in improving motor symptoms in PD. Deep brain stimulation (DBS), which is the second largest finding after levodopa, is still the first choice of operative treatment for PD, however, other operative therapies such as ablative therapy (radiofrequency, stereotactic radiosurgery, focused ultrasound thermal ablation, laser interstitial thermal therapy) have almost the same effectiveness. with DBS. As primary care physicians, it is very important for neurologists to understand the role in operative therapy that is currently developing. Keywords: Parkinson's disease, surgery, neurologist, therapy.