Abstract
An analysis of various models of a continuous stirred-tank bioreactor (CSTB) showed that those based on the specific uptake rate of substrate described the dynamics of the CSTB satisfactorily for controlling the parameters after a disturbance so that all substrate introduced into the bioreactor was utilized. The maximum values of dilution rate D max and/or substrate concentration S 0 max in the feed after a step increase in D and/or S 0 respectively which could be achieved without causing cell washout were measured and compared with those calculated using a “short-cut” method. It was found that the calculated values of D max and S 0 max were lower by approximately 20% than the experimental results. Thus the values of D max and S 0 max predicted by the short-cut method were not substantial underestimates and can be considered safe for the operation of a CSTB utilizing inhibitory substrates.
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