Abstract
Abstract To obtain a near optimal solution for operating procedure synthesis under safety constraint, in this paper, we intended to apply a meta-heuristic method termed differential evolution (DE). Compared with the previous approaches, we have shown DE's ability to derive such an operating sequence that is adaptive to various practical requirements and serves easy operation manner. Since the algorithm is straightforward and flexible to manage various conditions appearing in real-world applications, we can claim great promise of the proposed approach. In a case study, we applied the proposed method to safety mixing operation of acrylic acid synthesis process and validated its adaptability under various significant practical conditions.
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