Abstract
Current AUA/EUA guidelines recommend obtaining a genetic work-up in men with non-obstructive azoospermia or severe oligospermia (<5 mil/mL). A recent retrospective cohort study suggests that Yq microdeletions are primarily found at a sperm concentration <0.5 mil/mL and that by lowering the concentration threshold for genetic testing, specificity could be increased and relative financial cost decreased without adversely affecting the sensitivity. Studies have shown that FSH is the best predictor of NOA in combination with testicular volume as well as a significant predictor of microdeletion presence. We hypothesized that the combination of sperm concentration and FSH would better predict the presence of chromosome abnormalities in infertile men.
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