Operant feeding and drinking in pigs following intracerebroventricular injection of synthetic cholecystokinin octapeptide

Abstract

Operant feeding and drinking was investigated in food- or water-deprived pigs following intracerebroventricular (ICV) injection of a saline solution containing synthetic cholecystokinin (CCK) octapeptide. In 17-hour food-deprived animals treated with 0, 5, 10, 20 or 40 units ICV, post-treatment food intake was significantly reduced in a dose-related manner but drinking was unaffected. In 22-hour water-deprived pigs treated with 0, 10 or 40 units CCK octapeptide ICV, no effect on drinking was apparent. Pigs injected intravenously with 40 units following 17 hours food deprivation did not reduce their food intake.