Open-Source Essential Protein Prediction Model by Integrating Chi-Square and Support Vector Machine

Abstract

Identification and analysis of protein play a vital role in drug design and disease prediction. There are several open-source applications that have been developed for identifying essential proteins which are based on biological or topological features. These techniques infer the possibility of proteins to be essential by using the network topology and feature selection, which can ignore some of the features to reduce the complexity and, subsequently, results in less accuracy. In the paper, the authors have used selenium driver to scrap the dataset. Later, the authors integrated the chi-square method with support vector machine for the prediction of essential proteins in baker yeast. Here, chi-square is a test of dissimilarity used for altering the record, and afterward, the support vector machine is used to classify the test dataset. The results show that the proposed model Chi-SVM model achieves an accuracy of 99.56%, whereas BC and CC achieved an accuracy of 84.0% and 86.0%. Finally, the proposed model is validated using Statistical performance measures such as PPA, NPA, SA, and STA.