Abstract
To investigate clinical, radiographic and microbiological outcome over 12months following open flap debridement of peri-implantitis with or without antibiotics. Peri-implantitis was surgically treated with or without Zithromax® in 19 control and 20 test individuals. Probing pocket depth (PPD), gingival inflammation (BOP), intra-oral radiographs and microbial samples were studied. Per protocol and intent-to-treat analyses were performed. The mean difference (reduction) in PPD values between baseline and month 12 in the test and control groups was 1.7mm (SD±1.1, 95% CI: 1.1, 2.3, p<.001) and 1.6mm (SD±1.5, 95% CI: 0.8, 2,4, p<.001), respectively. Data analysis failed to show study group differences for BOP, PPD, radiographic bone level and microbial load. Successful treatment (per protocol: PPD≤5mm, no BOP, no suppuration and no bone loss ≥0.5mm) at 12months in test and control groups was 7/15 (46.7%) and 4/16 (25.0%). Bacterial load reduction was similar in study groups with a temporary reduction following treatment. Surgical treatment of peri-implantitis with adjunctive systemic azithromycin did not provide 1-year clinical benefits in comparison with those only receiving open flap debridement.
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