Abstract
The Open Access Series of Imaging Studies is a series of magnetic resonance imaging data sets that is publicly available for study and analysis. The initial data set consists of a cross-sectional collection of 416 subjects aged 18 to 96 years. One hundred of the included subjects older than 60 years have been clinically diagnosed with very mild to moderate Alzheimer's disease. The subjects are all right-handed and include both men and women. For each subject, three or four individual T1-weighted magnetic resonance imaging scans obtained in single imaging sessions are included. Multiple within-session acquisitions provide extremely high contrast-to-noise ratio, making the data amenable to a wide range of analytic approaches including automated computational analysis. Additionally, a reliability data set is included containing 20 subjects without dementia imaged on a subsequent visit within 90 days of their initial session. Automated calculation of whole-brain volume and estimated total intracranial volume are presented to demonstrate use of the data for measuring differences associated with normal aging and Alzheimer's disease.
Highlights
The Open Access Series of Imaging Studies (OASIS) is a project aimed at making magnetic resonance imaging (MRI) data sets of the brain freely available to the scientific community
Subjects aged 18 to 96 years were selected from a larger database of individuals who had participated in MRI studies at Washington University, based on the availability of at least three acquired T1-weighted images, righthand dominance, and a recent clinical evaluation for older adults
Older subjects with and without dementia were obtained from the longitudinal pool of the Washington University Alzheimer Disease Research Center (ADRC)
Summary
The Open Access Series of Imaging Studies (OASIS) is a project aimed at making magnetic resonance imaging (MRI) data sets of the brain freely available to the scientific community. OASIS images and related measures serve as data sets for continued scientific exploration. Beginning with the initial set of images obtained from more than 400 individuals with and without dementia across the adult life span, OASIS data sets are selected to encourage investigation of high interest topics and provide data that would be difficult for individual laboratories to acquire. OASIS data are targets for researchers creating and furthering analytic techniques. Because the images are acquired from subjects over a range of ages and health conditions, OASIS data can be used to test the robustness and validity of techniques across the full range of the human brain’s varied landscapes. OASIS data can be used as benchmark targets for comparing similar analytic techniques.
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