Abstract

Background Recurrent miscarriage (RM) affects 1% -5% of the reproductive age population. It is recognised that the best care for RM is offered in a dedicated recurrent miscarriage clinic (RMC). While RM represents a significant burden to couples, the setup of RMCs involves substantial resource costs. This study reports on the cost impact to the Irish healthcare system of implementing a ‘best practice’ model of care for RMCs. Evidence from cost analysis plays an important role in informing the cost-effectiveness of interventions ensuring that those available resources are used efficiently. Methods A micro-costing approach was employed using a range of data sources, and techniques, to identify, measure, and value the resources required to implement the proposed model of care. Data were collected from March to September 2021. The cost analysis was calculated using the following components: 1. The initial set up costs of a best practice RMC, 2. The ongoing implementation costs of delivering a best practice RMC, and 3. The subsequent and related care pathway costs. Per patient costs were estimated within a best practice RMC using two scenarios (a typical versus a complex RM case). The cost estimates were extrapolated to estimate the cost impact to the Irish healthcare care system over a 1-year period using population data and published prevalence rates for RM. A sensitivity analysis was performed to control for the uncertainty in each of the parameters. Results The total cost to set up a best practice RMC is €37,321. The yearly on-going delivery cost is €6,212.25. The total cost for a RM patient who has another pregnancy after receiving investigations, treatment and reassurance scans ranges between €1,634.19 (typical) and €4,817.87 (complex). For a RM patient who does not conceive again, costs range from €1,245.77 (typical) to €4,317.87 (complex). Using population estimates, the total budget impact to the health service for women who experience ≥2 losses costs €61,927,630 (typical)/€20,336,229 (complex) for a pregnancy outcome and €22,480,630 (typical)/€7,78,437 (complex) for women who do not conceive. Sensitivity analysis identified RM investigations and treatments costs as the main cost drivers for per patient costs. Conclusion This study proposes a model of care for RMCs in Ireland, providing cost estimates at the patient and healthcare system level. While future studies should consider the cost-effectiveness of this model of care, this analysis provides a valuable first step in providing a breakdown of the resources and costs.

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