OP3-01 TEMPLATE-BASED LYMPHADENECTOMY REDUCED THE RISK OF REGIONAL NODE RECURRENCE IN PATIENTS WITH RENAL PELVIC CANCER

Abstract

You have accessJournal of UrologyOutstanding Posters: Oncology1 Apr 2014OP3-01 TEMPLATE-BASED LYMPHADENECTOMY REDUCED THE RISK OF REGIONAL NODE RECURRENCE IN PATIENTS WITH RENAL PELVIC CANCER Tsunenori Kondo, Isao Hara, Toshio Takagi, Yoshiki Kodama, Yasunobu Hashimoto, Junpei Iizuka, Kenji Omae, Eri Ikezawa, Kazuhiko Yoshida, and Kazunari Tanabe Tsunenori KondoTsunenori Kondo More articles by this author , Isao HaraIsao Hara More articles by this author , Toshio TakagiToshio Takagi More articles by this author , Yoshiki KodamaYoshiki Kodama More articles by this author , Yasunobu HashimotoYasunobu Hashimoto More articles by this author , Junpei IizukaJunpei Iizuka More articles by this author , Kenji OmaeKenji Omae More articles by this author , Eri IkezawaEri Ikezawa More articles by this author , Kazuhiko YoshidaKazuhiko Yoshida More articles by this author , and Kazunari TanabeKazunari Tanabe More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.2322AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES We previously reported improvement of patient survival by template-based lymphadenectomy in patients with renal pelvic cancer. It remains unclear, however, whether lymphadenectomy reduces the risk of recurrence in the regional nodes. In this study, we retrospectively examined how the extent of lymphadenectomy influenced regional node recurrence in these patients. METHODS From January 1988 through July 2013, we performed nephroureterectomy in 180 patients with non-metastatic (cN0M0) urothelial carcinoma of the renal pelvis at two Japanese institutes. Regional nodes were determined according to our previous mapping study: complete lymphadenectomy (CompLND) designates that all regional sites were dissected; incomplete lymphadenectomy (IncompLND) that all sites were not dissected. A 3rd group included those without lymphadenectomy (No-LND). Sites of recurrence were examined by imaging studies. RESULTS Five-years recurrence-free survival was significantly higher in the CompLND group than in the IncompLND or No LND groups (84.1%, 67.5%, 66.1%, p=0.04). The incidence of regional node recurrence was significantly lower in the CompLND group at 2.9% (2/67) than in the IncompLND at 18.1% (4/22) or No LND at 10.9% (10/91) groups (p=0.03). We divided the pattern of regional node recurrence into two categories, recurrence at sites of dissection (Intra-LND recurrence) and that outside these sites (Extra-LND recurrence). The Figure here shows that 2 patients with CompLND and 1 of 4 patients with IncompLND experienced Intra-LND recurrence, but all these patients showed pathological node metastases. Extra-LND recurrence was 0% in CompLND, 3/4 (75%) in IncompLND, and 10/10 (100%) in No LND. The incidence of distant metastasis without lymph node involvement was not significantly different among the 3 groups. Cancer-specific survival was significantly higher in the CompLND group than in the IncompLND or No LND groups (90.6% versus 65.0% versus 70.2%, p=0.03). CONCLUSIONS This multi-institutional study shows that template-based lymphadenectomy reduced the risk of regional node recurrence in patients with renal pelvic cancer, which appears to result in improved survival. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e851 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Tsunenori Kondo More articles by this author Isao Hara More articles by this author Toshio Takagi More articles by this author Yoshiki Kodama More articles by this author Yasunobu Hashimoto More articles by this author Junpei Iizuka More articles by this author Kenji Omae More articles by this author Eri Ikezawa More articles by this author Kazuhiko Yoshida More articles by this author Kazunari Tanabe More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...