OP22 * SOCIAL DEPRIVATION SHORTENS SURVIVAL IN PATIENTS WITH HIGH GRADE GLIOMA

Abstract

INTRODUCTION: Low socioeconomic status is associated with increased frequency of chronic conditions, a higher frequency of mental health illness, greater use of primary care and hospital services and a lower relative cancer survival for some of the commonest cancers. The impact of social deprivation on the survival of patents with glial tumours however is poorly understood. We examine the role of social deprivation on the survival of patients with glial tumours METHOD: We performed a retrospective analysis of clinical records of patients with histologically confirmed glial tumours treated at our institution between 2009 and February 2013. The overall survival (from time of tissue diagnosis) and index of multiple deprivation (IMD - 2010) were obtained. Potential confounding factors incorporated into a multivariable Cox regression model included age, gender, ethnicity, tumour location, neurosurgical procedure, antiepileptic drug taken and past medical history. RESULTS: 485 patients with WHO Grade II, III and IV glioma were identified with all five quintiles of deprivation classes represented. 96 patients fell into the most deprived class (1), while 49 patients were found to be within the least deprived class (5). Patients in the lowest socioeconomic class had a significantly worse survival compared with those in the least deprived class. (p = 0.03) The significance of this finding persisted even after incorporation into a cox multivariable regression model to take account for other factors likely to affect survival. CONCLUSION:This study highlights the importance of addressing social deprivation and its effects in the effort to improve patient outcomes for patients with high grade glioma.