OP20.05: First trimester detection of fetal anomalies in pregestational diabetes

Abstract

the transvaginal transducer. Continuing pregnancies were rescanned at 20–22 weeks. Pregnancies with major anomalies were offered termination. Actual structural anomalies among newborns from the studied group were obtained from our computerized database. Results: The average age of pregnant women was 30 years (95%CI: 26.1–34.8). The incidence of sonographically detectable anomalies diagnosed preand postnatally was 16.08 per 1000 (143/8889). 46.9% (67/143) of all anomalies were detected at the 11–14 week scan. The most common abnormalities in the first trimester were cystic hygroma (30/67), followed by omphalocoele (13/67), and megacystis (7/67). The detection rates for fetal abnormalities in the first trimester were: central nervous system defects 50% (4/8), neck anomalies 100% (30/30), neural tube defects (0%, 0/2), heart anomalies 7% (1/13) and limb defects 23% (3/11). Later in pregnancy, another 22.3% (32/143) of structural anomalies was detected. Overall, 69.2% (99/143) of all morphologic anomalies were detected prenatally. Conclusions: We were able to detect 46.9% of all fetal malformations during the routine first-trimester scan. Obviously, the second trimester scan cannot be abandoned, as it provides effective detection of other anomalies, especially those of the face and heart.