OP180: Mucosal malignancy with solid organ transplantation

Abstract

Purpose 1. Measure the prevalence of mucosal head and neck squamous cell carcinoma (HNSCC) using a large database of solid organ transplant recipients. 2. Assess the risk of malignancies considering organ type, age at transplant and use of immunosuppressive medications. 3. Investigate the impact of on overall survival of each patient subset. Methods A database containing all solid organ transplant recipients at UMHS was used, and medical records from 4125 patients transplanted from 1996 to 2006 were queried using EMERSE (Electronic Medical Record Search Engine), with a bundle of search terms designed to screen for target malignancies. Once cases were identified, analysis of differences in incidence based on transplant site and age was performed using a generalized linear model with transplant organ and age at transplant as predictors. For all patients transplanted in the year 2002, medication usage history and survival data were gathered for subgroup analysis of these endpoints. Results The transplant recipient cohort consisted of 59% kidney, 22% liver, 8% lung, 10% heart and 5% receiving dual organ transplant. Head and neck cancer (HNSCC) was diagnosed in 0.6% of patients (n = 26). The mean age (std., range) at transplant was 44 years (17, Conclusion Transplant recipients carry an elevated risk of mucosal malignancies. Older age is correlated with increased risk of malignancy and shorter post-transplant interval. There is a trend towards worse prognosis in HNSCC patients with solid organ transplant.