Abstract
Mean z-score, 95% CI and centile corresponding to the mean were calculated. One-sample t tests were carried out to verify if z-score distribution is equal to zero. Finally, we compared z-scores of male and female fetuses with Down syndrome (DS) by the means of two sample t test. Results: 132 CHA pregnancies was eligible for designed analysis, of which 80 cases with DS, 20 with Edwards syndrome (ES), 7 with Patau syndrome (PS), 17 with Turner syndrome (TS) and 8 with triploidy. The results are summarized in table. We proved no difference in growth pattern of fetuses with DS. The separate comparison of female and male fetuses with DS also revealed no significant difference (p>0,2). Otherwise, we observed significant growth restriction – similar in PS and TS (around 5th centile), severe in ES (0,5th centile) and the most striking in triploidies (<0,003th centile). Conclusions: Statistical analyses showed no significant difference in growth pattern of DS fetuses, regardless of their sex. By contrast, in TS, PS, ES and triploidy there was growth restriction of various extent, deepening in mentioned order.
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