Abstract

Screening all colorectal cancer (CRC) tumors for Lynch syndrome (LS) was first recommended in 2009. Universal tumor screening (UTS) for LS among all newly diagnosed cases of colorectal (CRC) and endometrial (EC) cancers continues to be a cost-effective genomic medicine intervention with top-tier evidence for reducing cancer morbidity and mortality that is recommended by multiple professional organizations. After over a decade of this recommendation, most individuals with LS remain undiagnosed. One reason is the variable implementation of UTS programs in healthcare systems.

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