Abstract
of follow-up (PWV2). Samples for FGF-23 and 25(OH)D3 were determined cross-sectionally. Patients were divided into two groups cccording to 25(OH)D3 levels: Insufficiency (group 1, 25(OH)D3 30 ng/mL). Results: Patients in Group 1 (n: 91) had significantly higher annual mean values of phosphorus, CaxP product and FGF-23 compared to Group 2 (n: 26) (p < 0.018, 0.044 and 0.046, respectively). Administered elementary calcium dose was significantly higher in Group 1 than in Group 2 (p < 0.014). Patients in Group 1 had higher PWV1 and PWV2 measurements compared to Group 2 (p < 0.018 and 0.011). Serum levels of 25(OH)D3 were negatively correlated with mean phosphorus (p = 0.039) and mean administered elemantary calcium dose (P= 0.017). On multivariate analysis, levels of 25(OH)D3 were independently associated with the adjusted dose of elementary calcium (P< 0.002). Conclusion: Low level of 25(OH)D3 is not only a primary risk factor for cardiovascular health but might occur as a result of high phosphorus level or high cumulative calcium intake. While targeting to control renal osteodistrophy and achieving a higher 25(OH)D3 and lower FGF 23 for better outcome, better phosphorus control and minimum calcium supplementation should be the priority in the plan.
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