Abstract
studied with specially developed catheter based high-resolution, real-time miniature ultrasound transducer. Each brain mantle and secondary brain vesicles could be clearly visualized, and thickness of telencephalon, diencephalon, mesencephalon and rhombencephalon were measured. The normal range of embryonic brain mantle measurements for each day of pregnancy was determined. A linear relationships were found between the gestational age and telencephalon thickness (R2 = 51.9%), diencephalon thickness (R2 = 62.2%), mesencephalon thickness (R2 = 59.2%), and rhombencephalon thickness (R2 = 47.8%), respectively. A linear relationships were also found between the crown-rump length and telencephalon thickness (R2 = 55.0%), diencephalon thickness (R2 = 58.3%), mesencephalon thickness (R2 = 55.0%), and rhombencephalon thickness (R2 = 52.3%), respectively. These results suggest that intrauterine sonography provide an accurate embryonic brain mantle measurement value in utero. Moreover, intrauterine sonography may become an important modality in future embryonal research and in detection of embryonic brain developmental disorders in the early first-trimester pregnancy.
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