OP0282 POVETACICEPT (ALPN-303; TACI vTD-Fc), AN ENHANCED, POTENT DUAL INHIBITOR OF BAFF AND APRIL, DEMONSTRATES GREATER TISSUE DISTRIBUTION VERSUS WILD-TYPE TACI-Fc IN ADULT MICE AND IMPROVED EFFICACY VERSUS WILD-TYPE TACI-Fc OR ANTI-CD20 IN THE IFNα-ACCELERATED NZB/W MOUSE MODEL OF SLE

Abstract

Background:Povetacicept (ALPN-303; TACI vTD-Fc)[1] is an enhanced, high affinity dual antagonist of BAFF (B cell activating factor) and APRIL (a proliferation inducing ligand), cytokines that play key roles in the...