OP0215 MENTAL HEALTH, SLEEP AND COGNITION CHARACTERISTICS IN RHEUMATOID ARTHRITIS AND ASSOCIATIONS WITH RHEUMATOID FACTOR STATUS IN THE UK BIOBANK

Abstract

Background:There are significant gaps in the literature regarding sleep, mental health, and cognition for people with rheumatoid arthritis (RA) despite being important aspects of patients’ overall quality of life. Similarly, there is a lack of understanding about the role of rheumatoid factor (RF) on these domains.Objectives:The aim of the current study was to characterize mental health, cognition, and sleep variables in people with RA and to compare these associations in people with positive RF (RF+) and negative RF (RF-) in a large population cohort.Methods:This cross-sectional study used baseline data from the UK Biobank cohort (n= 502,506) to compare people with and without RA and people that are RF+ versus RF- on a variety of sociodemographic, lifestyle, illness-related factors and depression, neuroticism, performance on cognitive tests and sleep-related factors. Logistic regression analyses were also performed to determine whether RF seropositivity was associated with mental health, cognition, and sleep variables. We adjusted for the covariates of age, sex, ethnicity, deprivation index, smoking status, BMI and alcohol intake.Results:In this sample 5,907 people self-reported having RA (1.17%), of which 74% were RF- and 26% were RF+. There were significant differences (p < 0.05) between people with and without RA for depression, neuroticism, nap during the day, getting up in the morning, insomnia, reaction time, fluid intelligence and prospective memory. There were significant differences (p < 0.05) between RF+ and RF- people for depression, neuroticism, sleep duration, nap during the day, getting up in the morning, insomnia, and reaction time. In the unadjusted regression analyses neuroticism (B=-0.06, SE= 0.01, p < 0.001), sleep duration (B=0.02, SE= 0.005, p < 0.001), nap during the day (OR=1.28, 95% CI: 1.02-1.65, p < 0.05) and reaction time (B=4.55, SE=0.53, p< 0.001) were significantly associated with RF status. After adjusting for covariates, only sleep duration (B=0.01, SE=0.005, p< 0.01) remained significant.Conclusion:The current study suggests that RA diagnosis and RF status are associated with differences in mental health, sleep, and cognition, highlighting the importance of addressing these aspects in clinical settings and future research.Disclosure of Interests:None declared