OP0156 Methotrexate increases expression of the cell cycle regulators lbh and p21 and reduces fibroblast-like synoviocyte proliferation after mitogen stimulation

Abstract

BackgroundActivated fibroblast-like synoviocytes (FLS) are key effector cells in the joint in rheumatoid arthritis (RA). Local FLS proliferation is responsible for synovial hyperplasia, a key feature of the RA synovium...