OP0129 Higher Expression of TNF Alpha-Induced Genes in the Synovium of Early RA Patients Correlates with Disease Activity, and Predicts Absence of Response to First Line Therapy

Abstract

BackgroundGene expression profiling studies indicate that IL6-related T cell activation, and TNFα-dependent cell proliferation are major targets of therapy in the RA synovium1. We investigated whether expression of these pathways...