OP0122 Synovial WNT and WISP1 Expression Induces Expression of Cartilage-Degrading Metalloproteinases in the Synovium

M H Van Den Bosch,P L Van Lent,F A Van De Loo,A E Van Erp,E N Blaney Davidson,W B Van Den Berg,A B Blom,P M Van Der Kraan

doi:10.1136/annrheumdis-2013-eular.327

OP0122 Synovial WNT and WISP1 Expression Induces Expression of Cartilage-Degrading Metalloproteinases in the Synovium

M H Van Den Bosch, P L Van Lent + Show 6 more

https://doi.org/10.1136/annrheumdis-2013-eular.327

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Journal: Annals of the Rheumatic Diseases

Publication Date: Jun 1, 2013

Affiliation: Radboud University Nijmegen, Radboud University Nijmegen Medical Centre

#Human Osteoarthritis #Osteoarthritis + Show 8 more

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Abstract

BackgroundAlthough many osteoarthritis (OA) patients show significant synovial involvement, consequences are largely unknown. Previously, we found strong upregulation of Wnts 2b and 16 and WISP1, a downstream protein of canonical...

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