OP01.06: Cardiovascular parameters in the prediction of mortality in early‐onset intrauterine growth restriction

Abstract

Methods: We examined 156 pregnant women in The Department of the Fetal Medicine and Gynecology of Medical University of Lodz in the years 2006–2009. At each pregnant woman were estimated biochemical markers in the first (PAPP-A + β-hCG) and in the second trimester (AFP, β-hCG, uE3triple test), they underwent 3 ultrasound scans (first at 11 to 13+6 weeks, second at 15 to 20 weeks and third at 22 to 27 weeks of pregnancy) with uterine artery Doppler examination. We observed the follow up of the pregnancies due to the PIH and IUGR. 2 study groups included 28 patients with PIH and 14 patients with IUGR, in the control group were 114 patients with uncomplicated pregnancies. Results: In study groups we observed: higher maternal serum concentration of β-hCG, higher percentage of the positive results biochemical prenatal tests and abnormal uterine artery Doppler waveform positive triple test was the strongest predictor of PIH and IUGR (PPV = 60.87% for PIH and PPV = 30.77% for IUGR). Conclusions: Biochemical markers and abnormal uterine artery Doppler waveform are associated with PIH and IUGR. These parameters can create the test showing the high-risk group of PIH and IUGR in pregnancy. These studies were carried out thanks to Science and Higher Education Ministry funds – grant registration no: N406 044 31/1354.