OP0088 Discovery of a novel anti-bone resorption compound, AS2690168, which inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappa B ligand (RANKL)

Abstract

BackgroundRANK/RANKL signaling is the pathway of osteoclast differentiation and activation. In many bone diseases, the balance of bone formation and bone resorption is impaired. In osteoporosis, bone resorption is predominant...