OP0075 TAS5315, A Novel Bruton's Tyrosine Kinase (BTK) Inhibitor, Demonstrates Potent Efficacy in Mouse Collagen-Induced Arthritis Model

F Hosoi,Y Nakachi,E Sasaki,T Utsugi,Y Iwasawa,D Akasaka,S Iguchi,K Yonekura,R Kaneko,Y Yoshiga

doi:10.1136/annrheumdis-2015-eular.3864

OP0075 TAS5315, A Novel Bruton's Tyrosine Kinase (BTK) Inhibitor, Demonstrates Potent Efficacy in Mouse Collagen-Induced Arthritis Model

F Hosoi, Y Nakachi + Show 8 more

https://doi.org/10.1136/annrheumdis-2015-eular.3864

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Journal: Annals of the Rheumatic Diseases	Publication Date: Jun 1, 2015
Citations: 3

Affiliation: Taiho Pharmaceutical (Japan), Institute of Medicinal Plant Development

#Bone Resorption Activity Of Osteoclast #Bruton's Tyrosine Kinase Inhibitor + Show 8 more

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BackgroundBruton's tyrosine kinase (BTK) is a member of the Tec family kinases, and is expressed in B cells, monocytes/macrophages, mast cells, basophils and osteoclast1,2. BTK is a critical effector molecule...

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