OP-005 Relation Between Platelet/Lymphocyte Ratio and Coronary Flow in Patients With ST-Segment Elevation Acute Myocardial Infarction Undergoing Primary Coronary Intervention

Abstract

Platelet/lymphocyte ratio (PLR) has been shown as an inflammatory biomarkers for coronary heart disease, but data regarding the association of PLR with coronary blood flow in ST-segment elevation myocardial infarction (STEMI) are lacking. We aimed to investigate the relationship between the PLR and no-reflow in patient with STEMI. In present study, we included 360 consecutive patients suffering from STEMI who underwent primary percutaneous coronary intervention (p-PCI), reperfused within 12 h of symptom onset. Patients were divided into 2 groups based on Thrombolysis In Myocardial Infarction (TIMI) flow Grade and Myocardial blush grade (MBG). No-reflow after p-PCI was defined as a coronary TIMI flow grade <= 2 after vessel re-canalized or TIMI flow grade 3 together with a final MBG < 2. The PLR values were significantly higher in patients with no-reflow than in those without no-reflow (283.7 ± 96.6 vs 251.8 ± 75.6 p <0.001). In regression analysis, PLR [odds ratio 1.18, 95% confidence interval (CI) 1.05-1.39; P <0.001]. In receiver operator characteristic curve analysis, optimal cut-off value of PLR to predict no-reflow was found as 162, with 70% sensitivity and 61% specificity. Furthermore, we found that a significant correlation between the PLR both the TIMI thrombus grade scale and C-reactive protein (r = 42, p <0.001 and r = 33, p <0.001, respectively). PLR on admission is a strong and independent predictor of poor coronary blood flow following p-PCI in patient with STEMI. This simple and readily avaible parameter may be a useful biomarker for stratification of risk in patients with STEMI.