OP0046 Decreased Circulating ILC2 Levels Correlate with Skin Fibrosis in Human Systemic Sclerosis and Are Associated with A Skewing of The ILC1/ILC2 Balance in The Skin

P Laurent,E Lazaro,J Séneschal,P Manicki,T Pradeu,J Constans,C Contin-Bordes,P Blanco,I Douchet,C Richez,P Duffau,M.-E Truchetet

doi:10.1136/annrheumdis-2016-eular.3604

OP0046 Decreased Circulating ILC2 Levels Correlate with Skin Fibrosis in Human Systemic Sclerosis and Are Associated with A Skewing of The ILC1/ILC2 Balance in The Skin

P Laurent, E Lazaro + Show 10 more

https://doi.org/10.1136/annrheumdis-2016-eular.3604

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Journal: Annals of the Rheumatic Diseases

Publication Date: Jun 1, 2016

Affiliation: University of Bordeaux, Hôpital Cardiologique du Haut-Lévêque, Société Française de Médecine Vasculaire

#Systemic Sclerosis #Innate Lymphoid Cells + Show 8 more

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Abstract

BackgroundInterleukin (IL)13 is considered as a key downstream mediator in the development of Systemic sclerosis (SSc) fibrosis1. The recently described type 2 innate lymphoid cells (ILC) produce higher amounts of...

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