OP.5B.02] SERUM URIC ACID AND BLOOD PRESSURE PATTERN IN YOUNG ADULT MEN BORN SMALL FOR GESTATIONAL AGE

Abstract

Objective: Although increased rates of cardiovascular events in subjects born small for gestational age (SGA) were reported, the mechanisms underlying these associations are not completely elucidated. Epidemiological evidence supports association between serum uric acid (sUA) and incidence of hypertension. Our aim was to investigate the relationship between sUA, vascular function and blood pressure (BP) levels in young men born SGA. Design and method: A total of 95 healthy men (21.0+0.89 years) born SGA and 90 healthy men (21.5+1.02 years) with normal intrauterine development (AGA) were enrolled. Anthropometric parameters, office and ambulatory blood pressure (BP), fasting blood glucose, lipid profile, eGFR, carotid intima media thickness (cIMT), pulse wave velocity (PWV), central systolic BP (c-SBP), augmentation index (Aix) were determined in all participants. Hyperuricemia was considered if sUA > 360 μmol/L. Birth parameters were obtained from medical records. Results: Higher sUA values were observed in SGA vs. AGA group (406 vs. 307 p < 0.001). Hyperuricemic SGA participants had higher BMI, waist circumference (p < 0.003), office SBP (p=0.021), central SBP(p = 0.022), increased BP variability (p = 0.021), lower eGFR (p = 0.021) and more often dyslipidemia (p < 0.001) which was not observed in AGA group. There were no differences in cIMT, Aix, PWV between two groups. Positive correlation was found between sUA and BMI and waist circumference in both groups. Negative correlation with eGFR (<0.001) was observed in SGA group. When prematurity was taken into account in SGA participants, sUA correlated positively with BP variability (p = 0.003), cIMT (p = 0.016) and negative with birth weight (p = 0.009). Multiple regression analysis showed BMI as the key determinant of SBP (ß = 0.427, p < 0.001). Conclusions: Our results support findings of clustering of cardiovascular risk factors in young adult men born SGA with increased sUA. We did not observed vascular function differences according to sUA levels. Hovewer, in SGA participants, subclinical changes in circadian BP pattern were observed mainly influencing levels and variability of systolic BP particularly in subgroup of premature born SGA which might be a consequence of altered endothelial function and increased vasoconstriction.