Abstract
OP-34 - Clinical features and possible prognostic factors in patients with marginal zone lymphoma: retrospective analysis from two centers
Highlights
Overall survival was significantly higher in patients with nodal marginal zone lymphoma than in extranodal and splenic marginal zone lymphoma patients. overall survival of patients who required treatment was 92.9 months while untreated patients was 58.4 months and there was no significant difference among the groups
The platelet count of untreated patients at the time of diagnosis were significantly higher than patients who received treatment
We demonstrated platelet count at the time of diagnosis as a predictive factor for future treatment need
Summary
Marginal zone lymphoma (MZL) is characterized by the proliferation of B cells in postgerminal centers found in mucosa-associated lymphoid tissue (MALT), lymph nodes, and the spleen [1]. MZL has indolent clinical course commonly and present with limited stage of disease [2]. MZL accounts 5–17% of all non-Hodgkin lymphomas (NHL) [3]. MZL includes three subtypes: extranodal (EMZL), splenic(SMZL) and nodal MZL (NMZL) depending on site of involvement [4]. Many morphologic and immunophenotypic features of these subtypes are similar with their indolent course, there are differences in frequency, pathogenesis, clinical presentation and treatment [5]. According to the 2016 Revised WHO Classification, extranodal MZL is the most frequent subtype while nodal MZL is the least common form [6]
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