Abstract
The aim of the present study was to demonstrate, through the analysis of novel parameter like PON1, that early changes in oxidative stress takes place in stable coronary artery disease (CAD) patients undergoing elective PCI with implantation of coronary stents. Methods: In this study 32 consecutive chronic stable angina patients (mean age 61 9.8 years, 75% male) undergoing PCI for management of single-vessel CAD (>70% stenosis in a major coronary artery) were included. PON1 enzyme activity were measured immediately before (t1) and just after the procedure (t2), as well as 24 hours later (t3), in order to serially evaluate the changes of oxidative stress parameters in PCI. Results: Baseline demographic, clinical and laboratorycharacteristics of the patients were demonstrated Table 1. When PON1 activities before (t1), immediately after (t2) and 24 hours after (t3) PCI procedurewere compared, a sustained decline was demonstrated (t3 t2 and t3, p 0.05, respectively). There was no correlation between serum PON1 activity and clinical and laboratory parameters of patients. Conclusion: We demonstrated, for the first time, that a substantial impairment of PON1 activity occurs after PCI in patients with stable CAD.We suggest that the PON1 assay may have the potential to be used as an early risk predictor for restenosis in patients undergoing elective PCI with implantation of BMS, a hypothesis which requires further studies.
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