Abstract
Acute rheumatic fever is an autoimmune inflammatory and multisystemic disease secondary to pharyngitis caused by group A streptococcus. In developing countries, acute rheumatic fever is the most common cause of acquired heart disease. Gelsolin is a calcium dependent, multifunctional actin regulatory protein circulating in plasma of healthy. Correlation between blood gelsolin levels and inflammatory conditions suggests the potential benefit of gelsolin as a prognostic marker. The aim of the present study was to appraise the association of gelsolin and acute rheumatic carditis in childhood.
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