OP.1D.04] SUBCLINICAL LEFT VENTRICULAR DIASTOLIC DYSFUNCTION AND INCIDENT TYPE 2 DIABETES MELLITUS

Abstract

Objective: Subclinical left ventricular (LV) diastolic dysfunction in diabetes mellitus (DM) is a common finding and represent an early sign of diabetic cardiomyopathy. Yet, the relations of LV diastolic dysfunction and incidence of type 2 DM remain undefined. Design and method: We followed up 1817 non-diabetic participants (mean age, 54 years; 48% men) free of cardiovascular disease from the Korean Genome and Epidemiology Study biennially for 6 years. LV structure and function were measured by tissue Doppler imaging echocardiography. Subclinical LV diastolic dysfunction was defined using E/Em ratio, and left atrial volume index, and age-specific cutoff limit for early diastolic (Em) velocity. Results: During 6-year follow-up, 273 participants (15%) developed type 2 DM. In a multivariate-adjusted regression model, lower Em velocity (odd ratio [OR], 0.858; 95% confidence interval [CI], 0.771 – 0.955; P = 0.005), higher E/Em ratio (OR, 1.076; 95% CI, 1.014 – 1.143, P = 0.016), and the presence of LV diastolic function (OR, 1.794; 95% CI, 1.286 – 2.504, P = 0.001) were associated with the development of type 2 DM in prediabetes. However, no echocardiographic parameters were independent predictors of incident type 2 DM in participants with normal glucose tolerance. Conclusions: In a community-based cohort undergoing 6 years of follow-up, progression to type 2 DM in prediabetic participants could be predicted by the presence of subclinical LV diastolic dysfunction. This association is independent of age, prevalence of overweight, obesity, and hypertension, and initial fasting blood glucose.