OP.1C.08] RELATIONSHIP BETWEEN WITHIN-VISIT BLOOD PRESSURE VARIABILITY AND SKELETAL MUSCLE MASS

Abstract

Objective: Sarcopenia, defined as loss of skeletal muscle mass and function with age, is an important health issue in aging society. Although, hemodynamic factor is considered to be an important contributor in the development of sarcopenia, there have been very few studies regarding this topic. Thus, we tried to investigate the relationship between blood pressure variability and skeletal muscle mass in nation-wide large population cohort. Design and method: This cross-sectional study was based on data acquired in the Korea National Health and Nutrition Examination Survey (KNHANES), conducted from 2009 to 2011 by the Korean Centers for Disease Control & Prevention. We included 14,482 participants (male 6,302, aged 20 years or older) for the analysis who had both blood pressure and whole-body dual energy X-ray absorptiometry (DXA) scan data. As an intra-individual within-visit blood pressure variability index, we calculated standard deviation (SD), coefficient of variation (CV), and maximum minus minimum BP difference (MMD) of systolic and diastolic blood pressure, which was measured 3 times. Appendicular skeletal muscle mass (ASM) was the sum of lean masses of both arms and legs. We adjusted ASM by height^2, weight, and body mass index. Results: Significant inverse relationship was observed between blood pressure variability index (SD, CV, and MMD) and adjusted ASM. Blood pressure variability index were significantly higher in the lowest ASM quintile group both in male and female participants (p < 0.001). In multivariate analysis, blood pressure variability index were significantly associated with ASM, even after adjusting confounding factors (p < 0.001). Conclusions: Using the national representative database, we showed significant inverse relationship between within-visit blood pressure variability and skeletal muscle mass in Korean population. Considering the underlying mechanism of increased blood pressure variability, hemodynamic influence may play an important role in the development of sarcopenia.