OP 10 Longitudinal assessment of cardiovascular risk factors after hypertensive disorders of pregnancy – Towards identifying a window of opportunity for screening and prevention

Abstract

Introduction Accumulating evidence consistently demonstrates an increased risk and accelerated development of cardiovascular disease (CVD) risk in women with a history of a hypertensive disorder of pregnancy (HDP). Guidelines emphasize the emerging need for the prevention of CVD in these women, but fail to provide uniform recommendations on commencement and time interval in screening these patients. Objective The aim of this study is to investigate development of blood pressure, lipids and fasting glucose levels over time in women with a history of HDP in order to identify a window of opportunity for screening and prevention. Methods We identified women with self-reported normotensive pregnancy and HDP (NP, n = 1811; HDP, n = 1005) within the PREVEND study, a Dutch population-based cohort with a follow-up of maximum of 5 visits with 3-year intervals. Development of blood pressure, lipids, fasting glucose and Framingham 10-years CVD scores was longitudinally assed using generalized estimating equations. Results HDP”s present with overall higher and faster increasing prevalence of hypertension (p = 0.005), dyslipidemia (p = 0.009) and glucose disturbances (p = 0.002), reflecting in the use of medication (p Conclusion Women with a history of HDP show early development of hypertension, dyslipidemia and glucose homeostasis disturbances. Based on this cohort study, calculated 10-years CVD risk and NNS indicate commencing CVRM screening in these women at age 45 would be feasible. Download : Download high-res image (385KB) Download : Download full-size image